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| THE SCIENCE A & G Active Serum Recapture the youthful luminosity of your skin with this next generation of biologics based skin formula with A & G Active Serum, developed by A & G Skin Solutions, Inc., a leading California-based stem cell research and development corporation. A & G Active Serum greatly reduces the appearance of lines and wrinkles by restoring your skins natural stores of growth factors and proteins that are diminished as we age. A & G Active Serum is formulated with a multitude of human growth factors derived from our patented stem cell technology. Our goal at A & G Cosmeceuticals is to provide you with a scientifically-based skin care system that is backed by laboratory research, clinical studies, and peer review. Developed by two leading medical school professors, A & G prides itself by being one of only a few skin care companies to offer medical grade products based on cutting-edge stem cell research and incorporating the highest concentrations of pure, unbuffered ingredients manufactured in FDA-approved labs. When an ingredient is "FDA Approved", it means that any claims found on packaging have been scientifically proven to be valid, safe, and effective. This involves clinical testing supported by documentation and verification of test results. It also includes an FDA inspection of the laboratory and production facilities. Growth Factors and Proteins A & G Active Serum is an anti-aging skin serum formulated with patent-pending technology for the delivery of key growth factors found in natural human skin. These natural human growth factors include TGF-b(1-3) [Transforming growth factor beta], PDGF [Platelet derived growth factor], GM-CSF [Granulocyte-macrophage colony-stimulating factor], and Interleukins (IL3, IL6-8). As we age, the production of these growth factors within skin is reduced, and leads to wrinkling and thinning of the skin. By re-introducing these factors through daily application of A & G Active Serum, damaged skin cells are repaired, and skin tissue regenerated. The visible results from A & G Active Serum are that the appearance of fine lines and wrinkles will be diminished, and smoother, more luminous skin will result. As the effects of A & G Active Serum work through your own natural processes of skin renewal, visible results will be noticed as soon as three days. Moderate skin renewal may occur within two weeks, but optimal improvement to your skin is generally not reached until after one month of daily use. Patients from an ongoing clinical study had the following results after only four weeks of use with A & G Active Serum1: 94% of the women saw
improvement in overall appearance of their skin
Antioxidants Along with a multitude of growth factors and other proteins, the highest concentration of antioxidants in the body is contained in the epidermal layer of the skin, forming a protective barrier for the living dermal layer and the internal body. With age, the concentration of antioxidants in the skin declines considerably. Without the protective capacity of this layer, damage to the skin increases. Only about 1% of orally ingested antioxidants will arrive at the skin. Antioxidants applied topically can help restore an effective barrier and help reduce further damage. Antioxidants are substances that prevent oxidation damage to cells. Some of the most well known antioxidants are vitamin A, vitamin C, vitamin E, and Pycnogenol®. By maintaining an ideal level of antioxidants at the skin level, we can control free radical and oxidation damage. The action of antioxidants can reduce or partially neutralize the harmful power of free radicals (FR). The combination of antioxidants and A & G Active Serum is a powerful and effective way to hinder FR activity. Oral ingestion is one way to supply antioxidant vitamins into skin, but body control mechanisms tightly regulate the levels of ingested vitamins. Furthermore, most people don't get adequate supplies of antioxidant nutrients through diet. Applying antioxidants topically is a way to increase skin levels to help protect against reactive oxygen species (ROS)—provided the antioxidants first get into the skin, and then are in a form the body can use. When applied topically, combination antioxidants can provide up to a four-fold antioxidant protection, and prevent the formation of thymine dimmers in irradiated skin.
Anti-wrinkling
effects of the mixture of vitamin C, vitamin E, Pycnogenol®, and evening
primrose oil, and molecular mechanisms on hairless mouse skin caused by
chronic ultraviolet B irradiation. BACKGROUND: Naturally occurring antioxidants were used to regulate the skin damage caused by ultraviolet (UV) radiation because several antioxidants have demonstrated that they can inhibit wrinkle formation through prevention of matrix metalloproteinases (MMPs) and/or increase of collagen synthesis. OBJECTIVE: We examined the effect of oral administration of the antioxidant mixture of vitamin C, vitamin E, pycnogenol, and evening primrose oil on UVB-induced wrinkle formation. In addition, we investigated the possible molecular mechanism of photoprotection against UVB through inhibition of collagen-degrading MMP activity or through enhancement of procollagen synthesis in mouse dorsal skin. METHODS: Female SKH-1 hairless mice were orally administrated the antioxidant mixture (test group) or vehicle (control group) for 10 weeks with UVB irradiation three times a week. The intensity of irradiation was gradually increased from 30 to 180 mJ/cm2. Microtopographic and histological assessment of the dorsal skins was carried out at the end of 10 weeks to evaluate wrinkle formation. Western blot analysis and EMSA were also carried out to investigate the changes in the balance of collagen synthesis and collagen degradation. RESULTS: Our antioxidant mixture significantly reduced UVB-induced wrinkle formation, accompanied by significant reduction of epidermal thickness, and UVB-induced hyperplasia, acanthosis, and hyperkeratosis. This antioxidant mixture significantly prevented the UVB-induced expressions of MMPs, mitogen-activated protein (MAP) kinase, and activation of activator protein (AP)-1 transcriptional factor in addition to enhanced type I procollagen and transforming growth factor-beta2 (TGF-beta2) expression. CONCLUSION: Oral administration of the antioxidant mixture significantly inhibited wrinkle formation caused by chronic UVB irradiation through significant inhibition of UVB-induced MMP activity accompanied by enhancement of collagen synthesis.
Anti-inflammatory
and skin-hydrating properties of a dietary supplement and topical
formulations containing oligomeric proanthocyanidins. BACKGROUND: Anti-inflammatory and skin hydration properties of a dietary supplement and two topical formulations (Anthogenol) with oligomeric proanthocyanidins were investigated. METHODS: Forty-two subjects were randomized into 2 groups: one taking the dietary supplement (100 mg/day) and the other without supplement. After 4 weeks, erythema was induced using UV radiation followed by treatment with topical cream or lotion. Erythema was measured for up to 72 h after irradiation. Skin hydration after one and two weeks of application of the cream and lotion was also measured in separate test fields. RESULTS: Both topical formulations led to a significant suppression of erythema formation and the dietary supplement led to an additional slightly stronger suppression. Thus 72 h after UV exposure and compared to the control fields of patients that had not taken a dietary supplement, erythema was slightly (13.2%) lower in the subjects that had taken a dietary supplement. The cream resulted in a maximal reduction of erythema of 45.9% (p = 0.0015), while the lotion resulted in a maximal reduction of 53.1% (p = 0.0002). Both topical formulations also increased skin hydration (by nearly 20%; p < 0.002 for all combinations of dietary supplementation and topical treatment) and the hydration was higher in the group taking the dietary supplement. CONCLUSION: The regular use of Anthogenol products may help to protect from free-radical-mediated skin inflammation and to increase skin hydration.
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